Journal: Frontiers in Genetics
Article Title: The Long Noncoding RNA RPS10P2-AS1 Is Implicated in Autism Spectrum Disorder Risk and Modulates Gene Expression in Human Neuronal Progenitor Cells
doi: 10.3389/fgene.2019.00970
Figure Lengend Snippet: Gene ontology results from the 143 genes with altered expression in RenCell CX cells following over-expression of RPS10P2-AS1 . Blue indicates enrichment of genes that are upregulated; black indicates enrichment of genes that are downregulated; the combination of enrichment scores is additive. Genes altered by RPS10P2-AS1 are enriched for genes involved in apoptosis, response to organic substance, neurotransmitter transport and synapse, indicating the RPS10P2-AS1 alters the ability of a neuron to respond to environmental challenge.
Article Snippet: Cell Culture: The human neuronal progenitor cell ReNcell CX was used in this study as the cells differentiate into cortical projection neurons (EMD Millipore, Darmstadt, Germany).
Techniques: Expressing, Over Expression